Kinetic Challenges Facing Oxalate, Malonate, Acetoacetate, and Oxaloacetate Decarboxylases

Effect of Oxalate and Malonate on Red Cell Metabolism

The addition of oxalate to blood stored in Citratephosphate-dextrose (CPD) produces a marked improvement in 2,3-diphosphoglycerate (2.3-DPG) preservation; an increase in 2.3-DPG levels can also be documented in short-term incubation studies. Oxalate is a potent in vitro inhibitor of red cell lactate dehydrogenase. monophosphoglycerate mutase, and pyruvate kinase (PK). In the presence of fructos...

The effect of oxalate and malonate on red cell metabolism.

The addition of oxalate to blood stored in Citrate-phosphate-dextrose (CPD) produces a marked improvement in 2,3-diphosphoglycerate (2,3-DPG) preservation; an increase in 2,3-DPG levels can also be documented in short-term incubation studies. Oxalate is a potent in vitro inhibitor of red cell lactate dehydrogenase, monophosphoglycerate mutase, and pyruvate kinase (PK). In the presence of fructo...

Challenges Facing Educational Research

Challenges facing radiology educators.

This article summarizes the current challenges faced by radiology educators. These are discussed under the headings of time available for education, financing education, what and how to teach, student evaluation, support infrastructure, and challenges to leadership.

Challenges Facing Production Grids

Today’s global communities of users expect quality of service from distributed Grid systems equivalent to that their local data centers. This must be coupled to ubiquitous access to the ensemble of processing and storage resources across multiple Grid infrastructures. We are still facing significant challenges in meeting these expectations, especially in the underlying security, a sustainable a...